Database/Anti-Seborrheic/Climbazole
100% petroleum · ISO 16128

Is Climbazole natural?

No. Synthetic azole antifungal built entirely from petrochemical chlorophenol and imidazole ring chemistry; no biosynthetic or fermentation route exists.

INCI nameClimbazole
CAS38083-17-9
FormulaC15H17ClN2O2 · 292.76 Da
FunctionAnti-Seborrheic · Antimicrobial
FeedstockManufactured by reacting 4-chlorophenol with imidazole and a…

How we scored it

Whole molecule (1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one) built from chlorophenol and imidazole, both petrochemical aromatics; no natural fragment present.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured by reacting 4-chlorophenol with imidazole and a ketone intermediate derived from petrochemical feedstocks. There is no commercial natural or fermentation-derived alternative route.

In plain English

A lab-made antifungal ingredient used in anti-dandruff shampoos and some preservative systems to control yeast and bacteria. Built entirely in a chemical plant from petroleum-derived building blocks.

CosIng definition: Climbazole is the heterocyclic organic compound that conforms to the formula:

Natural alternatives with the same function

Achillea Millefolium Extract 100% natural origin

An extract from yarrow, a traditional herb, used to refresh and condition skin and help control oiliness. It's…

 Achillea Millefolium Oil 100% natural origin

An essential oil steam-distilled from yarrow flowers, used for its scent and soothing, cleansing properties. It comes directly…

 Artemisia Annua Leaf Extract 100% natural origin

A leaf extract from sweet wormwood, used to condition skin and as a fragrance component. It is obtained…

 Capryloyl Glycine 100% natural origin

A deodorant, anti-microbial ingredient made by combining coconut-derived caprylic acid with the amino acid glycine. Used in deodorants…

 Capsicum Annuum Fruit Extract 100% natural origin

An extract of chilli pepper fruit used to condition skin and hair and to give a warming, astringent…

 Chelidonium Majus Extract 100% natural origin

An extract of the leaves and stems of greater celandine, traditionally used on oily or flaky skin conditions.

Structure

2D structure of Climbazole

1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one

PubChem CID 37907 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Climbazole. PubChem CID 37907. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3CLIMBAZOLE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4CLIMBAZOLE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=CLIMBAZOLE