Database/Skin Conditioning/Citrulline
100% natural origin · ISO 16128

Is Citrulline natural?

Yes. Amino acid obtained by microbial fermentation of plant sugars, or extracted from watermelon; no petrochemical fragment.

INCI nameCitrulline
CAS372-75-8
FormulaC6H13N3O3 · 175.19 Da
FunctionSkin Conditioning
FeedstockProduced by microbial fermentation of plant sugars, mirroring…

How we scored it

Citrulline C6H13N3O3, a non-proteinogenic amino acid; amino acids are fermentation/hydrolysate products, fully natural-origin. 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by microbial fermentation of plant sugars, mirroring other cosmetic amino acids; can also be extracted from watermelon, its richest natural source. No petrochemical route is used.

In plain English

An amino acid used for skin conditioning. It occurs naturally in watermelon and is produced commercially by fermenting plant sugars with bacteria.

Structure

2D structure of Citrulline

(2S)-2-amino-5-(carbamoylamino)pentanoic acid

PubChem CID 9750 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Citrulline. PubChem CID 9750. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3CITRULLINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4CITRULLINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=CITRULLINE