Database/Denaturant/Brucine Sulfate
100% natural origin · ISO 16128

Is Brucine Sulfate natural?

Yes. Brucine alkaloid is extracted from Strychnos nux-vomica seeds; the sulfate counter-ion is a mineral-derived fragment; both count as natural.

INCI nameBrucine Sulfate
CAS4845-99-2
FormulaC46H54N4O12S · 887.0 Da
FunctionDenaturant
FeedstockBrucine is extracted from Strychnos nux-vomica or S.…

How we scored it

Brucine (plant alkaloid, extracted) x2 + H2SO4 (mineral-derived counter-ion, natural per this site's convention) = C46H54N4O12S, 887/887 = 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Brucine is extracted from Strychnos nux-vomica or S. ignatii seeds, then converted to its sulfate salt with sulfuric acid. Total chemical synthesis of brucine is not used commercially.

In plain English

The sulfate salt of brucine, a bitter plant alkaloid extracted from Strychnos nux-vomica seeds, used in tiny amounts to deter product misuse.

Structure

2D structure of Brucine Sulfate

bis((4aR,5aS,8aR,13aS,15aS,15bR)-10,11-dimethoxy-4a,5,5a,7,8,13a,15,15a,15b,16-decahydro-2H-4,6-methanoindolo[3,2,1-ij]oxepino[2,3,4-de]pyrrolo[2,3-h]quinolin-14-one);sulfuric acid

PubChem CID 24721400 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Brucine Sulfate. PubChem CID 24721400. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3BRUCINE SULFATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4BRUCINE SULFATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=BRUCINE%20SULFATE