Database/Hair Conditioning/Biotinoyl Tripeptide-1
Mostly natural · ISO 16128

Is Biotinoyl Tripeptide-1 natural?

Mostly. The GHK tripeptide is built from fermentation-derived amino acids (natural); biotin is made by multi-step petrochemical total synthesis.

INCI nameBiotinoyl Tripeptide-1
CAS299157-54-3
FormulaC24H38N8O6S · 566.7 Da
FunctionHair Conditioning
FeedstockBiotinoyl Tripeptide-1 links the amino-acid tripeptide GHK (natural,…

How we scored it

Tripeptide-1 (GHK, amino-acid peptide, natural, ~339 Da) amide-bonded to biotin (petrochemical multi-step synthesis, ~227 Da). 339/567 ~ 0.60.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Biotinoyl Tripeptide-1 links the amino-acid tripeptide GHK (natural, built from fermentation-derived amino acids) to biotin, which is manufactured almost entirely by multi-step chemical synthesis from petrochemical intermediates. No commercially significant natural-extraction route exists for biotin.

In plain English

A peptide ingredient combining vitamin B7 (biotin) with a small chain of amino acids, used in hair and scalp products. The amino-acid part comes from fermentation; the biotin part is made synthetically in a chemical plant.

CosIng definition: Biotinoyl Tripeptide-1 is the reaction product of Biotin and Tripeptide-1.

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Structure

2D structure of Biotinoyl Tripeptide-1

(2S)-2-[[(2S)-2-[[2-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanoic acid

PubChem CID 11534242 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Biotinoyl Tripeptide-1. PubChem CID 11534242. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3BIOTINOYL TRIPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4BIOTINOYL TRIPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=BIOTINOYL%20TRIPEPTIDE-1