Database/Skin Conditioning/Betulinic Acid
100% natural origin · ISO 16128

Is Betulinic Acid natural?

Yes. Obtained from birch-bark betulin by oxidation; the oxidising reagent leaves no mass in the product, so all carbon is plant-derived.

INCI nameBetulinic Acid
CAS472-15-1
FormulaC30H48O3 · 456.7 Da
FunctionSkin Conditioning
FeedstockBetulinic acid is produced by extraction or mild…

How we scored it

Triterpene acid; every carbon traces to betulin from birch bark, oxidation reagents leave no mass (cf. azelaic acid precedent). 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Betulinic acid is produced by extraction or mild oxidation of betulin from birch bark, an abundant natural source. No petrochemical synthesis route is used commercially.

In plain English

A skin-conditioning compound found in birch bark, usually obtained by extracting or lightly modifying the bark's natural betulin. Every carbon in the final molecule traces back to the plant.

Structure

2D structure of Betulinic Acid

(1R,3aS,5aR,5bR,7aR,9S,11aR,11bR,13aR,13bR)-9-hydroxy-5a,5b,8,8,11a-pentamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-3a-carboxylic acid

PubChem CID 64971 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Betulinic Acid. PubChem CID 64971. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3BETULINIC ACID. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4BETULINIC ACID. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=BETULINIC%20ACID