Database/Skin Conditioning/Andrographolide
100% natural origin · ISO 16128

Is Andrographolide natural?

Yes. Entire molecule is a plant natural product obtained by extraction; no commercial total-synthesis route.

INCI nameAndrographolide
CAS5508-58-7
FormulaC20H30O5 · 350.4 Da
FunctionSkin Conditioning
FeedstockAndrographolide is produced by solvent extraction and crystallisation…

How we scored it

Single diterpenoid lactone isolated by extraction/crystallisation from Andrographis paniculata; no synthetic atoms added → 1.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Andrographolide is produced by solvent extraction and crystallisation from Andrographis paniculata leaves. No petrochemical synthetic route is used commercially.

In plain English

A naturally occurring plant compound extracted from the leaves of Andrographis paniculata, a bitter herb used in traditional medicine, used here as a skin-conditioning ingredient.

Structure

2D structure of Andrographolide

(3E,4S)-3-[2-[(1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylidene-3,4,4a,6,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one

PubChem CID 5318517 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Andrographolide. PubChem CID 5318517. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ANDROGRAPHOLIDE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ANDROGRAPHOLIDE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ANDROGRAPHOLIDE