Database/Skin Conditioning/Acetyl Tetrapeptide-9
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-9 natural?

Mostly. The peptide backbone is built from fermentation-derived amino acids and the only synthetic addition is the small acetyl cap from petrochemical acetic acid. The earlier value was calculated against an estimated 442 Da when the supplied formula gives 539.54 Da.

INCI nameAcetyl Tetrapeptide-9
CAS928006-50-2
FormulaC22H33N7O9 · 539.5 Da
FunctionSkin Conditioning
FeedstockA four-amino-acid peptide, made by peptide synthesis from…

How we scored it

The supplied formula C22H33N7O9 weighs 539.54 Da. The acetyl cap contributed by acetic acid (C2H3O) is 43.04 Da, leaving 496.50 Da of peptide built from amino acids, which are natural origin on this site. So 496.50/539.54 = 0.92.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

A four-amino-acid peptide, made by peptide synthesis from fermentation-derived amino acids, capped with an acetyl group from petrochemical acetic acid or acetic anhydride.

In plain English

A small peptide used to condition skin, made from amino acids with a small chemical cap added for stability. Most of its weight is naturally derived from amino acids; a small part is synthetic.

CosIng definition: Acetyl Tetrapeptide-9 is a reaction product of acetic acid and Tetrapeptide-9

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Structure

2D structure of Acetyl Tetrapeptide-9

(3S)-3-[[(2S)-2-acetamido-5-amino-5-oxopentanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(1H-imidazol-5-yl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid

PubChem CID 11606295 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Tetrapeptide-9. PubChem CID 11606295. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL TETRAPEPTIDE-9. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL TETRAPEPTIDE-9. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-9