Database/Humectant/Acetyl Tetrapeptide-5
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-5 natural?

Mostly. The peptide backbone is built from fermentation-derived amino acids and the only synthetic addition is the small acetyl cap from acetic anhydride. The earlier value was calculated against an estimated 560 Da when the supplied formula gives 492.49 Da.

INCI nameAcetyl Tetrapeptide-5
CAS820959-17-9
FormulaC20H28N8O7 · 492.5 Da
FunctionHumectant
FeedstockA four-amino-acid peptide, made by peptide synthesis from…

How we scored it

The supplied formula C20H28N8O7 weighs 492.49 Da. The acetyl cap contributed by acetic acid (C2H3O) is 43.04 Da, leaving 449.45 Da of peptide built from amino acids, which are natural origin on this site. So 449.45/492.49 = 0.91.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

A four-amino-acid peptide, made by peptide synthesis from fermentation-derived amino acids, then acetylated with acetic anhydride.

In plain English

A peptide ingredient marketed for use around the delicate eye area to support a firmer, smoother look. It is made from four linked amino acids with a small acetyl cap added during manufacture.

CosIng definition: Acetyl Tetrapeptide-5 is product obtained by the acetylation of Tetrapeptide-5

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Structure

2D structure of Acetyl Tetrapeptide-5

(2S)-2-[[(2S)-2-[[(2S)-2-(3-acetamidopropanoylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoic acid

PubChem CID 11620163 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Tetrapeptide-5. PubChem CID 11620163. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL TETRAPEPTIDE-5. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL TETRAPEPTIDE-5. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-5