Database/Skin Conditioning/Acetyl Tetrapeptide-40
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-40 natural?

Mostly. Amino acids come from fermentation or protein hydrolysate, while the N-terminal acetyl cap derives from petrochemical acetic anhydride.

INCI nameAcetyl Tetrapeptide-40
FunctionSkin Conditioning
FeedstockThe peptide is assembled from fermentation-derived amino acids…

How we scored it

Sequence not given; assumed tetrapeptide about 550 Da. Acetyl cap net C2H2O 42 Da is petrochemical (acetic anhydride); peptide about 508 Da natural. 508/550 = 0.92.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

The peptide is assembled from fermentation-derived amino acids and acetylated at the N-terminus with petrochemical acetic anhydride. No alternative route exists.

In plain English

A short chain of four amino acids with an acetyl group on one end, used to condition skin. The amino acids come from fermentation or plant protein; the acetyl end-cap comes from petrochemical acetic acid chemistry.

CosIng definition: Acetyl Tetrapeptide-40 is the product obtained by the acetylation of Tetrapeptide-40.

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL TETRAPEPTIDE-40. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL TETRAPEPTIDE-40. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-40