Database/Skin Protecting/Acetyl Tetrapeptide-3
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-3 natural?

Mostly. Amino-acid peptide backbone is natural, fermentation/hydrolysate origin; the acetyl cap comes from petrochemical acetic anhydride.

INCI nameAcetyl Tetrapeptide-3
CAS827306-88-7
FormulaC22H39N9O5 · 509.6 Da
FunctionSkin Protecting
FeedstockBuilt from amino acids joined into a tetrapeptide,…

How we scored it

Peptide backbone C20H37N9O4 (467.6) natural, amino-acid based; acetyl cap C2H2O (42.0) petrochemical; 467.6/509.6=0.92.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built from amino acids joined into a tetrapeptide, then capped with an acetyl group from acetic anhydride. The peptide backbone is natural; only the small acetyl cap is petrochemical.

In plain English

A lab-made peptide, a short chain of amino acids, with a small acetyl group attached; used as a skin-protecting ingredient in skincare formulas.

CosIng definition: Acetyl Tetrapeptide-3 is product obtained by the acetylation of Tetrapeptide-3

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Structure

2D structure of Acetyl Tetrapeptide-3

(2S)-2-[[(2S)-2-[[2-[[(2S)-2-acetamido-6-aminohexanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-6-aminohexanamide

PubChem CID 11752568 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Tetrapeptide-3. PubChem CID 11752568. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL TETRAPEPTIDE-3. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL TETRAPEPTIDE-3. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-3