Database/Skin Conditioning/Acetyl Tetrapeptide-22
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-22 natural?

Mostly. The peptide backbone from fermentation-derived amino acids is natural; only the small N-acetyl cap is petrochemical.

INCI nameAcetyl Tetrapeptide-22
CAS1295648-76-8
FormulaC26H45N9O6 · 579.7 Da
FunctionSkin Conditioning
FeedstockBuilt by coupling fermentation-derived amino acids (including histidine…

How we scored it

C26H45N9O6 = 579.7 Da; petrochemical N-acetyl cap adds ~42 Da (net C2H2O); natural peptide backbone = 537.7 Da; 537.7/579.7 = 0.93.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built by coupling fermentation-derived amino acids (including histidine and leucine) into a tetrapeptide, then capping the N-terminus with acetic acid/anhydride. The acetyl cap is the only petrochemical-derived fragment.

In plain English

A lab-made peptide built from amino acids, including histidine and leucine, with a small acetyl cap added. Used in anti-aging skincare to help condition skin.

CosIng definition: Acetyl Tetrapeptide-22 is the reaction product of acetic acid and Tetrapeptide-22

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Structure

2D structure of Acetyl Tetrapeptide-22

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid

PubChem CID 51346978 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Tetrapeptide-22. PubChem CID 51346978. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL TETRAPEPTIDE-22. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL TETRAPEPTIDE-22. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-22