Database/Skin Conditioning/Acetyl Tetrapeptide-2
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-2 natural?

Mostly. Amino-acid backbone is natural; only the small N-terminal acetyl cap, from petrochemical acetic anhydride, is non-natural.

INCI nameAcetyl Tetrapeptide-2
CAS757942-88-4
FormulaC26H39N5O9 · 565.6 Da
FunctionSkin Conditioning
FeedstockAssembled from amino acids (fermentation/protein-hydrolysate origin) and capped…

How we scored it

Peptide backbone (natural, amino acids) ~524 Da + acetyl cap net addition ~42 Da (petrochemical, acetic anhydride). 524/566≈0.93.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Assembled from amino acids (fermentation/protein-hydrolysate origin) and capped with an acetyl group from acetic anhydride. The peptide bonds themselves add no petrochemical mass.

In plain English

Acetyl Tetrapeptide-2 is a short chain of amino acids used in skincare to condition skin. It is built almost entirely from natural amino acid building blocks, with a tiny synthetic acetyl cap added at one end.

CosIng definition: Acetyl Tetrapeptide-2 is product obtained by the acetylation of Tetrapeptide-2

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Structure

2D structure of Acetyl Tetrapeptide-2

(3S)-3-[[(2S)-2-acetamido-6-aminohexanoyl]amino]-4-[[(2S)-1-[[(1S)-1-carboxy-2-(4-hydroxyphenyl)ethyl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-oxobutanoic acid

PubChem CID 91936905 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Tetrapeptide-2. PubChem CID 91936905. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL TETRAPEPTIDE-2. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL TETRAPEPTIDE-2. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-2