Database/Skin Conditioning/Acetyl Tetrapeptide-18
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-18 natural?

Mostly. Four natural amino acids assembled into a peptide, capped with a small petrochemical acetyl group.

INCI nameAcetyl Tetrapeptide-18
FunctionSkin Conditioning
FeedstockBuilt from amino acids (fermentation/protein-hydrolysate origin) joined into…

How we scored it

~386 Da natural tetrapeptide (4 fermentation-derived amino acids) + ~42 Da petrochemical acetyl cap (from acetic anhydride); 386/428 ~ 0.90 (exact sequence/MW not given).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built from amino acids (fermentation/protein-hydrolysate origin) joined into a tetrapeptide, then N-acetylated using petrochemical acetic anhydride. The acetyl cap is a small fraction of total mass.

In plain English

A small lab-assembled chain of amino acids with an added acetyl group, used in anti-aging skincare to help condition the skin.

CosIng definition: Acetyl Tetrapeptide-18 is the product of the reaction of Acetic Acid and Tetrapeptide-18

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL TETRAPEPTIDE-18. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL TETRAPEPTIDE-18. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-18