Database/Skin Conditioning/Acetyl Tetrapeptide-15
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-15 natural?

Mostly. The peptide backbone is built from fermentation-derived amino acids and the only synthetic addition is the small acetyl cap from petrochemical acetic acid. The earlier value was calculated against an estimated 442 Da when the supplied formula gives 613.71 Da.

INCI nameAcetyl Tetrapeptide-15
CAS928007-64-1
FormulaC34H39N5O6 · 613.7 Da
FunctionSkin Conditioning
FeedstockA four-amino-acid peptide, made by peptide synthesis from…

How we scored it

The supplied formula C34H39N5O6 weighs 613.71 Da. The acetyl cap contributed by acetic acid (C2H3O) is 43.04 Da, leaving 570.67 Da of peptide built from amino acids, which are natural origin on this site. So 570.67/613.71 = 0.93.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

A four-amino-acid peptide, made by peptide synthesis from fermentation-derived amino acids, capped with an acetyl group from petrochemical acetic acid or acetic anhydride.

In plain English

A small peptide used to condition skin, made from amino acids with a small chemical cap added to stabilise it. Most of its weight is naturally derived from amino acids; a small part is synthetic.

CosIng definition: Acetyl Tetrapeptide-15 is the reaction product of acetic acid and Tetrapeptide-15

Natural alternatives with the same function

Abelmoschus Esculentus Fruit Extract 100% natural origin

An extract made from okra pods, used to condition skin in cosmetic formulas. Produced by extracting the fruit,…

 Abelmoschus Manihot Flower Extract 100% natural origin

A flower extract from a hibiscus relative, used to condition and soothe skin. Made by extracting the flowers…

 Abies Alba Extract 100% natural origin

An extract of the European silver fir (Abies alba), a conifer from the mountains of Europe. It is…

 Acacia Concinna Fruit Extract 100% natural origin

An extract from shikakai fruit, a plant traditionally used in Indian hair and skin care. It conditions skin…

 Acacia Dealbata Flower Extract 100% natural origin

An extract of mimosa flowers used to help condition skin. Made by extracting compounds from the fragrant yellow…

 Acacia Dealbata Flower Wax 100% natural origin

A soft wax from mimosa flowers used to condition skin and add emollience. It is derived directly from…

Structure

2D structure of Acetyl Tetrapeptide-15

(2S)-1-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide

PubChem CID 16657387 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Tetrapeptide-15. PubChem CID 16657387. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL TETRAPEPTIDE-15. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL TETRAPEPTIDE-15. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-15