Database/Skin Conditioning/Acetyl Tetrapeptide-11
Mostly natural · ISO 16128

Is Acetyl Tetrapeptide-11 natural?

Mostly. Amino acids composing the peptide are natural (fermentation or hydrolysate); only the acetyl cap is petrochemical.

INCI nameAcetyl Tetrapeptide-11
FunctionSkin Conditioning
FeedstockBuilt from amino acids joined into a four-residue…

How we scored it

Tetrapeptide backbone (amino acids, fermentation/hydrolysate-derived, natural, est. approx 440Da) + acetyl cap (petrochemical acetic anhydride, approx 42Da) = 440/482 approx 0.92.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built from amino acids joined into a four-residue peptide, then acetylated with petrochemical acetic anhydride. The peptide backbone dominates the molecule's mass and is natural origin.

In plain English

A lab-made peptide (a short chain of amino acids) with an acetyl cap, used in anti-aging skincare to condition skin. Amino acids are fermentation-derived; the acetyl group comes from petrochemical acetic acid.

CosIng definition: Acetyl Tetrapeptide-11 is the reaction product of Acetic Acid and Tetrapeptide-11

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL TETRAPEPTIDE-11. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL TETRAPEPTIDE-11. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20TETRAPEPTIDE-11