Database/Skin Conditioning/Acetyl Pentapeptide-35
Mostly natural · ISO 16128

Is Acetyl Pentapeptide-35 natural?

Mostly. The five amino acids come from fermentation or protein hydrolysis (natural), while the N-terminal acetyl cap comes from petrochemical acetic anhydride.

INCI nameAcetyl Pentapeptide-35
FunctionSkin Conditioning
FeedstockDominant route: solid-phase peptide synthesis from fermentation-derived amino…

How we scored it

Sequence not given; assume pentapeptide ~560 Da (559 natural) + acetyl C2H3O 43 Da petrochemical. 559/(559+43) = 0.93.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route: solid-phase peptide synthesis from fermentation-derived amino acids, then N-acetylation with acetic anhydride. No alternative route is commercially significant.

In plain English

A short chain of five amino acids with an acetyl group on one end, used to condition skin. The amino acids come from fermentation or protein hydrolysis and are joined by chemical synthesis; the acetyl cap comes from petrochemical acetic anhydride.

CosIng definition: Acetyl Pentapeptide-35 is the product obtained by the acetylation of Pentapeptide-35.

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL PENTAPEPTIDE-35. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL PENTAPEPTIDE-35. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20PENTAPEPTIDE-35