Database/Skin Conditioning/Acetyl Methionine
Route-dependent · ISO 16128

Is Acetyl Methionine natural?

It depends. Unlike most amino acids, most methionine is made by chemical synthesis from petrochemical feedstocks, not fermentation.

INCI nameAcetyl Methionine
CAS1115-47-5
FormulaC7H13NO3S · 191.25 Da
FunctionSkin Conditioning
FeedstockMost methionine is synthesized from petrochemical acrolein, methanethiol…

Why the score varies

This ingredient is made commercially by more than one route, and ISO 16128 scores the feedstock actually used. Without a supplier certificate of origin the value cannot be claimed.

RouteFeedstockNOIShareNotes
Chemical synthesis (acrolein + methanethiol + hydrogen cyanide, hydrolysis)propylene-derived acrolein, methanethiol, natural-gas HCN0.00majority, ~90%+ of global supply
Fermentation-derived L-methionine, then acetylatedglucose fermentation0.78minority, natural-certified grades
Ask your supplier. A batch-specific certificate of origin or bio-based carbon test (ASTM D6866) settles which route applies.

How we scored it

Methionine backbone: dominant route is chemical synthesis from petrochemical acrolein/methanethiol/HCN (0.0); minority fermentation route is natural. Acetyl cap always petrochemical. Not a single value.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Most methionine is synthesized from petrochemical acrolein, methanethiol and hydrogen cyanide; a smaller fermentation route from glucose exists for natural-certified grades.

In plain English

A modified form of the amino acid methionine, used to condition the skin.

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Structure

2D structure of Acetyl Methionine

(2S)-2-acetamido-4-methylsulfanylbutanoic acid

PubChem CID 448580 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Methionine. PubChem CID 448580. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL METHIONINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL METHIONINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20METHIONINE