Database/Emollient/Acetyl Hydroxyproline
Mostly natural · ISO 16128

Is Acetyl Hydroxyproline natural?

Mostly. Hydroxyproline from protein hydrolysate is natural; acetyl cap comes from petrochemical acetic anhydride.

INCI nameAcetyl Hydroxyproline
CAS33996-33-7
FormulaC7H11NO4 · 173.17 Da
FunctionEmollient · Hair Conditioning
FeedstockMade by acetylating hydroxyproline, derived from collagen hydrolysate…

How we scored it

Hydroxyproline backbone (131.13-1H=130.13, protein hydrolysate/fermentation) + acetyl cap C2H3O (43.04, petrochemical) = 173.17. 130.13/173.17=0.75.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Made by acetylating hydroxyproline, derived from collagen hydrolysate or fermentation, with acetic anhydride. No significant alternative route exists.

In plain English

A moisturizing ingredient made by acetylating hydroxyproline, an amino acid from collagen. Helps skin and hair retain moisture and feel conditioned.

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Structure

2D structure of Acetyl Hydroxyproline

(2S,4R)-1-acetyl-4-hydroxypyrrolidine-2-carboxylic acid

PubChem CID 65784 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Hydroxyproline. PubChem CID 65784. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL HYDROXYPROLINE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL HYDROXYPROLINE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HYDROXYPROLINE