Database/Skin Conditioning/Acetyl Hexapeptide-8 Amide
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-8 Amide natural?

Mostly. Glu, Met, Gln and Arg are fermentation or protein-hydrolysate amino acids and count as natural, while the N-terminal acetyl cap comes from petrochemical acetic anhydride.

INCI nameAcetyl Hexapeptide-8 Amide
FunctionSkin Conditioning
FeedstockBuilt by solid-phase peptide synthesis from fermentation-derived amino…

How we scored it

Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2, 889 Da. Petrochemical: acetyl cap CH3CO 43 Da. Natural amino-acid residues 846 Da. 846/889 = 0.95 (matches Acetyl Hexapeptide-3).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built by solid-phase peptide synthesis from fermentation-derived amino acids, with acetic anhydride capping the N-terminus. Protecting groups, resin and coupling agents leave no mass in the product.

In plain English

A short synthetic peptide (closely related to the ingredient sold as Argireline) used for skin conditioning. It is assembled from six amino acids made by fermentation and capped with an acetyl group.

CosIng definition: Acetyl Hexapeptide-8 Amide is the product obtained by the acetylation of Hexapeptide-8 in which the C-terminus is an amide.

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL HEXAPEPTIDE-8 AMIDE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL HEXAPEPTIDE-8 AMIDE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-8%20AMIDE