Database/Skin Protecting/Acetyl Hexapeptide-7
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-7 natural?

Mostly. The standard amino acids are natural; methylnorleucine is a synthetic amino acid and the acetyl cap is petrochemical.

INCI nameAcetyl Hexapeptide-7
FunctionSkin Protecting
FeedstockSolid-phase peptide synthesis, N-terminal acetylation with acetic anhydride.

How we scored it

Assumed one each of alanine, arginine, histidine, phenylalanine and tryptophan (fermentation amino acids, natural) and methylnorleucine (synthetic, non-protein amino acid, 127.2 Da), acetyl cap 42.0 Da petrochemical; 715.8/885.0 = 0.81. Sequence from the CosIng description; exact composition not published.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Solid-phase peptide synthesis, N-terminal acetylation with acetic anhydride.

In plain English

A lab-made chain of amino acids with a small acetyl group attached, used to protect skin. The peptide backbone is fermentation-derived; the acetyl cap is a petrochemical addition.

CosIng definition: Alanine, synthetic hexapeptide with arginine, histidine, methylnorleucine, phenylalanine and tryptophan, acetyl derivatives; Acetyl hexapeptide-7 is the reaction product of acetic acid and hexapeptide-7

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL HEXAPEPTIDE-7. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL HEXAPEPTIDE-7. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-7