Database/Skin Conditioning/Acetyl Hexapeptide-49
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-49 natural?

Mostly. Amino acids from fermentation or protein hydrolysate are natural origin, while the acetyl cap comes from petrochemical acetic anhydride.

INCI nameAcetyl Hexapeptide-49
CAS1969409-70-8
FormulaC51H57N9O8 · 924.1 Da
FunctionSkin Conditioning
FeedstockMade by solid-phase peptide synthesis from fermentation-derived L-amino…

How we scored it

Six proteinogenic amino acids (Phe x3, Trp, His, Val by formula) 881 Da natural + N-acetyl cap C2H3O 43 Da petrochemical; 881/924 = 0.95. Matches Acetyl Hexapeptide-3.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Made by solid-phase peptide synthesis from fermentation-derived L-amino acids, then capped with acetic anhydride. Only the petrochemical acetyl cap lowers the value; no alternative route.

In plain English

A short signal peptide (six amino acids with an acetyl cap) used in skin-care products to condition the skin. The amino acids are fermentation-derived and are linked together in a laboratory.

CosIng definition: Acetyl Hexapeptide-49 is the product obtained by the acetylation of Hexapeptide-49.

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Structure

2D structure of Acetyl Hexapeptide-49

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoic acid

PubChem CID 162625096 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Hexapeptide-49. PubChem CID 162625096. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL HEXAPEPTIDE-49. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL HEXAPEPTIDE-49. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-49