Database/Skin Conditioning/Acetyl Hexapeptide-39
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-39 natural?

Mostly. Hexapeptide backbone from natural/fermentation amino acids; only the small N-acetyl cap is counted as petrochemical, per this site's convention.

INCI nameAcetyl Hexapeptide-39
CAS1382088-38-1
FormulaC32H51N7O10 · 693.8 Da
FunctionSkin Conditioning
FeedstockProduced by chemically acetylating Hexapeptide-39, a peptide built…

How we scored it

Hexapeptide (natural amino acids) + N-acetyl cap. Acetyl adds ~42 Da net to MW 693.8: natural fraction = (693.8-42)/693.8 = 0.94.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Produced by chemically acetylating Hexapeptide-39, a peptide built from natural amino acids. Directly analogous to the calibrated Acetyl Hexapeptide-3 case.

In plain English

A small peptide used to help skin look firmer, made of natural amino acids joined together and capped with a tiny acetyl group.

CosIng definition: Acetyl Hexapeptide-39 is the product obtained by the acetylation of Hexapeptide-39

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Structure

2D structure of Acetyl Hexapeptide-39

(2S,3S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-methylpentanamide

PubChem CID 66550605 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Hexapeptide-39. PubChem CID 66550605. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL HEXAPEPTIDE-39. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL HEXAPEPTIDE-39. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-39