Database/Skin Conditioning/Acetyl Hexapeptide-38
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-38 natural?

Mostly. Peptide backbone is from fermentation-derived amino acids; only the N-terminal acetyl group, from acetic anhydride, is petrochemical.

INCI nameAcetyl Hexapeptide-38
CAS1400634-44-7
FormulaC30H55N9O10 · 701.8 Da
FunctionSkin Conditioning
FeedstockHexapeptide-38 is assembled from fermentation amino acids, then…

How we scored it

Hexapeptide including serine, fermentation-derived, plus acetyl group (petrochemical, 42Da of 701.8 total MW). 1-42/701.8=0.94.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Hexapeptide-38 is assembled from fermentation amino acids, then acetylated with acetic anhydride. No natural acetylation route is in commercial use.

In plain English

A lab-assembled chain of amino acids, including serine, with a small acetyl cap, used as a skin-conditioning ingredient. The peptide portion is fermentation-derived; the acetyl group is a minor petrochemical addition.

CosIng definition: Acetyl Hexapeptide-38 is the product obtained by the acetylation of Hexapeptide-38

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Structure

2D structure of Acetyl Hexapeptide-38

(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-hydroxybutanoic acid

PubChem CID 155801571 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Hexapeptide-38. PubChem CID 155801571. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL HEXAPEPTIDE-38. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL HEXAPEPTIDE-38. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-38