Database/Skin Conditioning/Acetyl Hexapeptide-37
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-37 natural?

Mostly. The peptide backbone from natural amino acids is natural origin; only the small N-acetyl cap counts as petrochemical.

INCI nameAcetyl Hexapeptide-37
CAS1447824-16-9
FormulaC22H35N7O8 · 525.6 Da
FunctionSkin Conditioning
FeedstockSynthesised from fermentation-derived amino acids then N-acetylated with…

How we scored it

C22H35N7O8 = 525.6 Da; petrochemical N-acetyl cap adds ~42 Da (net C2H2O); natural peptide backbone = 483.6 Da; 483.6/525.6 = 0.92.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Synthesised from fermentation-derived amino acids then N-acetylated with acetic acid/anhydride, similar to other acetyl-hexapeptides used for skin conditioning. The acetyl cap is the only petrochemical fragment.

In plain English

A lab-made peptide of six amino acids with a small acetyl cap added, used in anti-aging skincare to help condition the skin.

CosIng definition: Acetyl Hexapeptide-37 is the product obtained by the acetylation of Hexapeptide-37

Natural alternatives with the same function

Abelmoschus Esculentus Fruit Extract 100% natural origin

An extract made from okra pods, used to condition skin in cosmetic formulas. Produced by extracting the fruit,…

 Abelmoschus Manihot Flower Extract 100% natural origin

A flower extract from a hibiscus relative, used to condition and soothe skin. Made by extracting the flowers…

 Abies Alba Extract 100% natural origin

An extract of the European silver fir (Abies alba), a conifer from the mountains of Europe. It is…

 Acacia Concinna Fruit Extract 100% natural origin

An extract from shikakai fruit, a plant traditionally used in Indian hair and skin care. It conditions skin…

 Acacia Dealbata Flower Extract 100% natural origin

An extract of mimosa flowers used to help condition skin. Made by extracting compounds from the fragrant yellow…

 Acacia Dealbata Flower Wax 100% natural origin

A soft wax from mimosa flowers used to condition skin and add emollience. It is derived directly from…

Structure

2D structure of Acetyl Hexapeptide-37

(2S)-1-[2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-acetamido-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]propanoyl]amino]acetyl]amino]acetyl]pyrrolidine-2-carboxamide

PubChem CID 169450578 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Hexapeptide-37. PubChem CID 169450578. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL HEXAPEPTIDE-37. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL HEXAPEPTIDE-37. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-37