Database/Skin Conditioning/Acetyl Hexapeptide-31
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-31 natural?

Mostly. Peptide backbone is fermentation-derived; only the small acetyl cap is petrochemical.

INCI nameAcetyl Hexapeptide-31
FunctionSkin Conditioning
FeedstockHexapeptide-31 is assembled from fermentation amino acids then…

How we scored it

Hexapeptide-31 (fermentation-derived amino acids, est. MW~800) + acetyl cap (petrochemical acetic anhydride, +42Da)(~0.95).
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Hexapeptide-31 is assembled from fermentation amino acids then acetylated with acetic anhydride. No natural acetylation route is in commercial use.

In plain English

A synthetic peptide with a small acetyl cap, used as a skin-conditioning ingredient. Built from fermentation-derived amino acids with a minor petrochemical modification.

CosIng definition: Acetyl Hexapeptide-31 is the product obtained by the acetylation of Hexapeptide-31.

Natural alternatives with the same function

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL HEXAPEPTIDE-31. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL HEXAPEPTIDE-31. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-31