Database/Skin Conditioning/Acetyl Hexapeptide-19
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-19 natural?

Mostly. Six amino acids from fermentation or hydrolysate are natural, while the N-terminal acetyl cap comes from petrochemical acetic anhydride.

INCI nameAcetyl Hexapeptide-19
FunctionSkin Conditioning
FeedstockDominant route is solid-phase synthesis from fermentation-derived amino…

How we scored it

Sequence not given; assume about 800 Da peptide. Acetyl cap C2H2O 42 Da petrochemical (acetic anhydride); residues natural: 758/800 = 0.95, matching Acetyl Hexapeptide-3.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Dominant route is solid-phase synthesis from fermentation-derived amino acids with N-terminal acetylation. Peptide-coupling reagents and protecting groups leave no mass; only the acetyl cap is petrochemical.

In plain English

A short chain of six amino acids with an acetyl group on one end, used to condition skin. The amino acids come from fermentation or protein hydrolysis, and the acetyl cap is made from petrochemical acetic anhydride.

CosIng definition: Acetyl Hexapeptide-19 is the product obtained by the acetylation of Hexapeptide-19.

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References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2ACETYL HEXAPEPTIDE-19. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  3. 3ACETYL HEXAPEPTIDE-19. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-19