Database/Skin Conditioning/Acetyl Hexapeptide-1
Mostly natural · ISO 16128

Is Acetyl Hexapeptide-1 natural?

Mostly. All six amino acids are fermentation/protein-hydrolysate products; only the N-terminal acetyl group traces to petrochemical acetic anhydride.

INCI nameAcetyl Hexapeptide-1
CAS448944-47-6
FormulaC43H59N13O7 · 870.0 Da
FunctionSkin Conditioning
FeedstockMade by linking fermentation-derived amino acids into a…

How we scored it

Hexapeptide (Ala+Arg+His+Leu+Phe+Trp, -5 H2O) ~829 Da natural + acetyl cap (C2H2O, 42 Da) petrochemical = 871 Da total; 829/871 = 0.95
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Made by linking fermentation-derived amino acids into a hexapeptide, then N-acetylating with acetic anhydride. The acetyl cap is the only non-renewable mass in the molecule.

In plain English

A lab-made chain of six amino acids with an acetyl group attached, used in skincare to condition skin. The amino acids come from fermentation; the acetyl group is made from petrochemical acetic acid.

CosIng definition: Acetyl Hexapeptide-1 is reaction product of Alanine, arginine, histidine, leucine, phenylalanine and tryptophane hexapeptide with acetic acid

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Structure

2D structure of Acetyl Hexapeptide-1

(2S)-2-acetamido-N-[(2S)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]hexanamide

PubChem CID 10129683 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Hexapeptide-1. PubChem CID 10129683. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL HEXAPEPTIDE-1. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL HEXAPEPTIDE-1. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20HEXAPEPTIDE-1