Database/Skin Conditioning/Acetyl Dipeptide-3 Aminohexanoate
Mostly natural · ISO 16128

Is Acetyl Dipeptide-3 Aminohexanoate natural?

Mostly. Arginine and alanine are fermentation amino acids (natural); the acetyl cap and 6-aminohexanoic acid spacer are petrochemical/caprolactam-derived.

INCI nameAcetyl Dipeptide-3 Aminohexanoate
CAS1176133-78-0
FormulaC17H32N6O5 · 400.5 Da
FunctionSkin Conditioning
FeedstockBuilt from the natural amino acids arginine and…

How we scored it

Ac-Arg-Ahx-Ala, MW 400.5. Natural: Arg(156)+Ala(88)=244. Petrochemical: acetyl cap(43, this site's convention)+6-aminohexanoic acid/caprolactam spacer(113)=156. 244/400=0.61.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Built from the natural amino acids arginine and alanine joined via a 6-aminohexanoic acid spacer, a synthetic caprolactam-derived linker, then N-acetylated. No alternative commercial route reported.

In plain English

A lab-designed peptide-like molecule used to condition skin, built mainly from natural amino acids joined by a small synthetic linker and capped with an acetyl group.

CosIng definition: Acetyl Dipeptide-3 Aminohexanoate is the reaction product of acetic acid and Dipeptide-3 with 6-aminohexanoic acid

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Structure

2D structure of Acetyl Dipeptide-3 Aminohexanoate

(2S)-2-[6-[[(2S)-2-acetamido-5-(diaminomethylideneamino)pentanoyl]amino]hexanoylamino]propanoic acid

PubChem CID 169450577 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Dipeptide-3 Aminohexanoate. PubChem CID 169450577. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL DIPEPTIDE-3 AMINOHEXANOATE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL DIPEPTIDE-3 AMINOHEXANOATE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20DIPEPTIDE-3%20AMINOHEXANOATE