Database/Skin Conditioning/Acetyl Decapeptide-3
Mostly natural · ISO 16128

Is Acetyl Decapeptide-3 natural?

Mostly. A decapeptide of natural amino acids carrying one petrochemical acetyl cap, a small fraction of the total mass.

INCI nameAcetyl Decapeptide-3
CAS935288-50-9
FormulaC68H95N19O17 · 1450.6 Da
FunctionSkin Conditioning
FeedstockThe peptide backbone is synthesised from fermentation-derived amino…

How we scored it

Decapeptide-3 (10 natural amino acids, ~1408.6 Da) + acetyl cap from acetic acid (petrochemical) ~42.0 Da = 1450.6 Da; 1408.6/1450.6 = 0.97.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

The peptide backbone is synthesised from fermentation-derived amino acids; the N-terminal acetyl group is added using acetic acid/anhydride, a petrochemical reagent.

In plain English

A lab-made peptide of 10 amino acids with an acetyl group attached, used to condition skin. Almost all its weight comes from natural amino acid building blocks.

CosIng definition: Acetyl Decapeptide-3 is the product formed by the reaction of acetic acid and Decapeptide-3

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Structure

2D structure of Acetyl Decapeptide-3

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxypropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-6-amino-N-[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]hexanamide

PubChem CID 91936932 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 2Acetyl Decapeptide-3. PubChem CID 91936932. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 3ACETYL DECAPEPTIDE-3. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 4ACETYL DECAPEPTIDE-3. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=ACETYL%20DECAPEPTIDE-3