Database/Hair Dyeing/6-Hydroxyindole
100% petroleum · ISO 16128

Is 6-Hydroxyindole natural?

No. Made industrially from petrochemical feedstocks via indole ring synthesis; no natural commercial route exists.

INCI name6-Hydroxyindole
CAS2380-86-1
FormulaC8H7NO · 133.15 Da
FunctionHair Dyeing
FeedstockManufactured synthetically from petroleum-derived aniline-type precursors via indole…

How we scored it

Synthetic indole derivative from petrochemical aniline-based indole synthesis -> 0.0.
What counts. ISO 16128-2 scores the atoms that remain in the final ingredient. Reagents, solvents, catalysts and protecting groups used during manufacture leave no mass behind and are not counted.

Where it comes from

Manufactured synthetically from petroleum-derived aniline-type precursors via indole ring synthesis. Used as a hair-dye coupler with no natural alternative.

In plain English

A synthetic dye ingredient made from petroleum feedstocks, used as a colour-developing coupler in permanent hair dyes.

Natural alternatives with the same function

Structure

2D structure of 6-Hydroxyindole

1H-indol-6-ol

PubChem CID 524508 ↗

References

  1. 1ISO 16128-1:2016 and ISO 16128-2:2017 — Guidelines on technical definitions and criteria for natural and organic cosmetic ingredients and products. ISO, Geneva.
  2. 26-Hydroxyindole. PubChem CID 524508. National Center for Biotechnology Information. pubchem.ncbi.nlm.nih.gov ↗
  3. 36-HYDROXYINDOLE. CosIng — European Commission cosmetic ingredient database. ec.europa.eu/cosing ↗
  4. 46-HYDROXYINDOLE. CosIng u2014 European Commission database for information on cosmetic substances and ingredients. https://ec.europa.eu/growth/tools-databases/cosing/search?search=6-HYDROXYINDOLE